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A facile phenol synthesis. An improved route to 6-methoxy-2-tetralone.

✍ Scribed by Roger L. Kidwell; Stephen D. Darling


Publisher
Elsevier Science
Year
1966
Tongue
French
Weight
194 KB
Volume
7
Category
Article
ISSN
0040-4039

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Synthesis of 8-substituted xanthines via
✍ Ma Dong; Mikhail Sitkovsky; Amy E. Kallmerten; Graham B. Jones πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 French βš– 177 KB

A one-pot route to 8-substituted xanthines has been developed from 5,6-diaminouracils and carboxaldehydes. The process, promoted by (bromodimethyl)sulfonium bromide, is mild and efficient and eliminates the need for external oxidants. Yields are good and the process is applicable to a range of subst