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A Facile Method for Direct Conversion of Dihydrofuroquinolones to Dihydropyrroloquinolones

โœ Scribed by Soo Kim, Sung; Gyeong Cheon, Hyae; Kyu Kang, Seung; Kgun Yum, Eul; Choi, Joong-Kwon


Book ID
115460102
Publisher
Japan Institute of Heterocyclic Chemistry
Year
1998
Tongue
English
Weight
106 KB
Volume
48
Category
Article
ISSN
0385-5414

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An improved method for direct conversion
โœ Thomas A. Engler; Kelly Furness; Sushant Malhotra; Clive Diefenbacher; Joshua R. ๐Ÿ“‚ Article ๐Ÿ“… 2003 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 107 KB

Treatment of heteroaryl-aldehydes with diethyl cyanophosphonate in the presence of a catalytic amount of LiCN affords phosphorylated cyanohydrins which are reduced in situ with SmI 2 to give heteroaryl-acetonitriles in generally good overall yields (50-100%). The generality of the process is demonst