A Facile Green Synthesis and Anti-Cancer Activity of bis-Arylhydrazononitriles, Triazolo[5,1-c][1,2,4]triazine, and 1,3,4-Thiadiazolines
β Scribed by M. Riyadh, Sayed; M. Gomha, Sobhi; D. Khalil, Khaled; M. El-Zanaty, Ali
- Book ID
- 120166909
- Publisher
- Japan Institute of Heterocyclic Chemistry
- Year
- 2013
- Tongue
- English
- Weight
- 324 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0385-5414
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The novel and versatile cyanomethyl 2amino-4-methylthiazolyl ketone (5) was prepared by treatment of bromomethyl 2-amino-4-methyl thiazolyl ketone (4) with potassium cyanide. Reaction of 5 with heterocyclic diazonium salts 6a,b and 10 afforded the corresponding hydrazones 7a,b and 11, respectively.