A facile generation of enolates from silyl enol ethers by potassium ethoxide
โ Scribed by Wensheng Yu; Zhendong Jin
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 101 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
Cyclic silyl enol ethers were successfully cleaved by EtOK to generate the corresponding enolates. Reactions with EtOK were faster and the corresponding enolates could be trapped by electrophiles and oxidants to give the kinetic products exclusively.
๐ SIMILAR VOLUMES
Treatment of enol silyl ethers with the mild nitrating agent tetranitromethane gives good yields of unitroketones at room temperature and below.
Various chlorodifluoromethyl ketones can be converted to the corresponding 2,2-difluoro enol silyl ethers in good yields, by the action of zinc dust and chlorotrimethylsilane in dry acetonitrile at 60ยฐC. Since the findings of improved methods for the preparation of enol silyl ethers, 1 it has well b