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A Facile and Efficient Synthesis of (Purin-6-yl)alanines

✍ Scribed by Čapek, Petr; Pohl, Radek; Hocek, Michal


Book ID
120191289
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
96 KB
Volume
69
Category
Article
ISSN
0022-3263

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Synthesis of (purin-6-yl)methylphosphona
✍ Zbyněk Hasník; Radek Pohl; Michal Hocek 📂 Article 📅 2010 🏛 Elsevier Science 🌐 French ⚖ 318 KB

Three approaches to the synthesis of the title (purin-6-yl)methylphosphonates were investigated and compared. While, the Arbuzov reaction of 6-(iodomethyl)purines with triethyl phosphite did not work, Michaelis-Becker alkylation of the sodium salt of diethyl phosphonate with 6-(mesyloxymethyl)purine