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A Facile and Efficient Synthesis of Novel 1,2,4-Triazolo[5,1-b]quinazolin-9-one Derivatives

✍ Scribed by Nasser R. El-Brollosy; Mohamed F. Abdel-Megeed; Afaf R. Genady

Publisher: Springer Vienna
Year: 2001
Tongue: English
Weight: 131 KB
Volume: 132
Category: Article
ISSN: 0026-9247
DOI: 10.1007/s007060170047

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## Abstract The reaction of 3‐__N__‐(2‐mercapto‐4‐oxo‐4__H__‐quinazolin‐3‐yl)acetamide (**1**) with hydrazine hydrate yielded 3‐amino‐2‐methyl‐3__H__‐[1,2,4]triazolo[5,1‐__b__]quinazolin‐9‐one (**2**). The reaction of **2** with __o__‐chlorobenzaldehyde and 2‐hydroxy‐naphthaldehyde gave the corresp