A Facile Anchoring of the Bisphosphonate Moiety into Alcohols and Phenols Through Copper Carbenoid Mediated O—H Insertion Reaction.

A facile synthesis of aminomethylene bis

A facile synthesis of aminomethylene bisphosphonates through rhodium carbenoid mediated N–H insertion reaction. Application to the preparation of powerful uranyl ligands

✍ Delphine Lecerclé; Sandra Gabillet; Jean-Marie Gomis; Frédéric Taran 📂 Article 📅 2008 🏛 Elsevier Science 🌐 French ⚖ 137 KB

A straightforward procedure ensuring the anchoring of bisphosphonate moiety onto aromatic amines is described. The procedure yields aminoaryl 1,1-bisphosphonates known to display multiple biological activities. The described methodology has also been applied to the synthesis of ligands whose uranyl-