✦ LIBER ✦
A facile synthesis of aminomethylene bisphosphonates through rhodium carbenoid mediated N–H insertion reaction. Application to the preparation of powerful uranyl ligands
✍ Scribed by Delphine Lecerclé; Sandra Gabillet; Jean-Marie Gomis; Frédéric Taran
- Book ID
- 104095046
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- French
- Weight
- 137 KB
- Volume
- 49
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A straightforward procedure ensuring the anchoring of bisphosphonate moiety onto aromatic amines is described. The procedure yields aminoaryl 1,1-bisphosphonates known to display multiple biological activities. The described methodology has also been applied to the synthesis of ligands whose uranyl-binding properties have been studied.