A Facile Access to Fluorinated Pyrrolidines via Catalytic Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides with Methyl α -Fluoroacrylate
✍ Scribed by Yan, Dingce; Li, Qinghua; Wang, Chunjiang
- Book ID
- 118757195
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 577 KB
- Category
- Article
- ISSN
- 0256-7660
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📜 SIMILAR VOLUMES
## Abstract The first catalytic asymmetric 1,3‐dipolar cycloaddition of azomethine ylides with various sterically hindered α,α,β‐trisubstituted 2‐alkylidene‐cycloketones has been developed successfully with silver acetate/TF‐BiphamPhos complex for the construction of spiro heterocyclic compounds co
1,3-Dipolar cycloaddition reaction of cinnamaldehyde with azomethine ylides generated through decarboxylation of iminium or oxazolidinone intermediate formed by the reaction of L-proline with cinnamaldehydes is reported. The stereoselective reaction provides an efficient access to the highly functio