A highly enantioselective synthesis of (À)-and (+)-juglomycin A, a quinone antibiotic is described. The synthesis is completed in eight steps, and 19% overall yield and in a high enantioselectivity of 99.5% [for (À)-juglomycin A] and 98.5% [for (+)-juglomycin A]. The synthetic strategy features an e
A Dötz benzannulation route to the enantioselective synthesis of (−)- and (+)-juglomycin A
✍ Scribed by Rodney A. Fernandes; Vijay P. Chavan
- Book ID
- 113929525
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 576 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0957-4166
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
The efficient synthesis of an enantiopure Iricyclic lactam starting from (S)-5-isopropoxypyrrolin-2-one is described. The racemate of this tricyclic laetam is an intennedmte in our previously published total synthesis of racemic gelsemine, so that the present work paves the way for the synthesis of
An enantioselective route for the total synthesis of forskolin, a potent activator of adenylate cyclase, has been developed which is based on reduction of dienone 3 to the (S)-alcohol4 and conversion in two steps to tricyclic lactone 9, obtained in optically pure form simply by recrystallization. A