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A dynamical model of apoptosis and its role in tumor progression

✍ Scribed by Pasquale Laise; Duccio Fanelli; Annarosa Arcangeli


Book ID
113547083
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
664 KB
Volume
17
Category
Article
ISSN
1007-5704

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## Abstract Tumors frequently acquire resistance to apoptosis that is expected to contribute to malignant phenotype and reduce sensitivity to treatment. In fact, inactivation of __p53__ tumor suppressor gene resulting in suppression of apoptosis serves as a negative prognostic marker. Surprisingly,