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A Double Ring-Closing Metathesis Approach for the Synthesis of β-C-Trisaccharides

✍ Scribed by Maarten H. D. Postema; Jared L. Piper; Venu Komanduri; Lei Liu


Publisher
John Wiley and Sons
Year
2004
Tongue
English
Weight
187 KB
Volume
43
Category
Article
ISSN
0044-8249

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Ring-Closing Metathesis in the Synthesis
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## Abstract Syntheses of novel 16‐membered macrocyclic peptidomimetics are reported, which employ iterative peptide coupling followed by high yielding ring‐closing metathesis (RCM) as the key cyclization step. The target macrocyclic compounds include examples containing a (2__S__)‐amino‐8‐oxodecano

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The application of the ring-closing metathesis (RCM) castanospermine ( ) is presented. The utilisation of two RCM steps in the synthetic sequence leading to the multicyclic reaction to the construction of a wide variety of nitrogencontaining ring systems is described. The examples include ABCDE nucl