✦ LIBER ✦

A double blind comparison of alprazolam, diazepam and placebo in the treatment of anxious out-patients

✍ Scribed by K. Davison; R. G. Farquharson; M. C. Khan; A. Majid

Publisher: Springer
Year: 1983
Tongue: English
Weight: 344 KB
Volume: 80
Category: Article
ISSN: 0033-3158
DOI: 10.1007/bf00432110

No coin nor oath required. For personal study only.

✦ Synopsis

The anxiolytic effects of alprazolam, a triazolobenzodiazepine, were evaluated in a double-blind 28-day comparison with diazepam and placebo in 46 out-patients suffering from anxiety states of moderate to severe intensity. Alprazolam 1.5-3 mg per day was found to be of at least equivalent anxiolytic effect to 15-30 nag diazepam per day, and there was evidence of antidepressant activity by alprazolam, but not diazepam, in neurotic depression.

Side-effects occurred least often with alprazolam and were minor in nature. Laboratory data showed no changes attributable to alprazolam even in a patient who swallowed 25 capsules (7.5 rag).

It was concluded that alprazolam is a safe and effective anxiolytic which is well-tolerated and also shows some antidepressant activity.

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