A dose escalation and pharmacokinetic study of biweekly pegylated liposomal doxorubicin, paclitaxel and oxaliplatin in patients with advanced solid tumors
β Scribed by Kostas Kalbakis; Periklis Pappas; Charalambos Kouroussis; Lambros Vamvakas; Antonia Kalykaki; Nikolaos Vardakis; Martha Nikolaidou; Marios Marselos; Vassilis Georgoulias; Dimitris Mavroudis
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 391 KB
- Volume
- 62
- Category
- Article
- ISSN
- 0344-5704
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## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEGβLD) and docetaxel have singleβagent activity in several malignancies. The authors conducted a Phase I trial to evaluate the maximum tolerated dose (MTD), toxicities, and effect of dose sequencing of this combination in patients with ad
## Abstract ## BACKGROUND Pegylated liposomal doxorubicin (PEGβLD) and gemcitabine have singleβagent activity in breast and ovarian carcinoma patients. We conducted a Phase I trial to evaluate the maximum tolerated dose (MTD) and toxicities of this combination in patients with advanced malignancie