A dithiol ester version of Dieckmann condensation

✍ Scribed by Hsing-Jang Liu; Hoi Kiong Lai

• Book ID: 104237625
• Publisher: Elsevier Science
• Year: 1979
• Tongue: French
• Weight: 173 KB
• Volume: 20
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)86100-1

✦ Synopsis

The Dieckmann condensatlonl 1s an Important cycllzatlon process whereby esters of dlcarboxyllc acids are converted into versatile cyclic f3-keto esters.

The commonly used procedures Involve prolonged treatment of dlesters under strongly basic condltlons, often at elevated temperature. We wish to report a dlthlol ester version of the Dleckmann condensation, which proceeds readily under markedly milder condltlons to give, In good yields, cyclic B-keto thiol esters (Eq. 1).