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A Direct Synthesis of Nucleoside Analogues Homologated at the 3′- and 5′-Positions.

✍ Scribed by Juergen Schmidt; Bernd Eschgfaeller; Steven A. Benner


Publisher
John Wiley and Sons
Year
2003
Weight
48 KB
Volume
34
Category
Article
ISSN
0931-7597

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📜 SIMILAR VOLUMES


A Direct Synthesis of Nucleoside Analogs
✍ Jürgen Schmidt; Bernd Eschgfäller; Steven A. Benner 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 German ⚖ 238 KB

## Abstract A new route is presented to prepare analogs of nucleosides homologated at the 3′‐ and 5′‐positions. This route, applicable to both the D‐ and L‐enantiomeric forms, is suitable for the preparation of monomeric bis‐homonucleosides needed for the synthesis of oligonucleotide analogs. It be

Sucrose analogues modified at position 3
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Conditions for the large-scale (molar) oxidation of sucrose by Agrobacterium tumefaciens were improved, thus leading to homogeneous solutions of 3-ketosucrose in 40% yield. Treatment of this solution with hydroxylamine or methoxylamine afforded the corresponding oximes 3a and 3b (isolated as acetate