𝔖 Bobbio Scriptorium
✦   LIBER   ✦

A direct method for the alkylation of adenosine nucleosides at position 8.

✍ Scribed by Derek H.R. Barton; Charles J.R. Hedgecock; Edgar Lederer; William B. Motherwell

Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
118 KB
Volume
20
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

✦ Synopsis

Alkylation of adenosine derivatives at carbon 8 can be conveniently achieved by lithiation followed by reaction with an alkyl halide. Selective methods for the direct modification of purine nucleoside derivatives are surprisingly few in number.

📜 SIMILAR VOLUMES

A Direct Synthesis of Nucleoside Analogs
A Direct Synthesis of Nucleoside Analogs Homologated at the 3′- and 5′-Positions
✍ Jürgen Schmidt; Bernd Eschgfäller; Steven A. Benner 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 German ⚖ 238 KB

## Abstract A new route is presented to prepare analogs of nucleosides homologated at the 3′‐ and 5′‐positions. This route, applicable to both the D‐ and L‐enantiomeric forms, is suitable for the preparation of monomeric bis‐homonucleosides needed for the synthesis of oligonucleotide analogs. It be

A novel method for stereospecific fluori
A novel method for stereospecific fluorination at the 2′-arabino-position of pyrimidine nucleoside: synthesis of [18F]-FMAU
✍ Nashaat Turkman; Juri G. Gelovani; Mian M. Alauddin 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 French ⚖ 169 KB

## Abstract Direct fluorination of a pyrimidine nucleoside at the 2′‐arabino‐position has been deemed to be extremely difficult, if not impossible. The conventional synthesis of 2′‐deoxy‐2′‐fluoro‐5‐methy‐1‐β‐D‐arabinofuranosyluracil (FMAU) and its 5‐substituted analogs involves stereospecific fluo