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A DIRECT IODINATION METHOD WITH IODINE AND SILVER TRIFLATE FOR THE SYNTHESIS OF SPECT AND PET IMAGING AGENT PRECURSORS

✍ Scribed by Mulholland, G. Keith; Zheng, Qi-Huang


Book ID
120449752
Publisher
Taylor and Francis Group
Year
2001
Tongue
English
Weight
283 KB
Volume
31
Category
Article
ISSN
0039-7911

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## Abstract Iodocaramiphen (2) is a selective muscarinic antagonist which binds __in vitro__ with high affinity and selectivity to the M~1~ subtype of the muscarinic receptor. We report the synthesis of iodine‐125 labeled iodocaramiphen ([^125^I]‐2) via a tributylstannyl intermediate (3) in 50% rad