✦ LIBER ✦

A diastereoselective synthesis of 4(RS), 6(SR)-mercaptomethylmevalonolactone, a key intermediate in the preparation of a new class of inhibitors of HMG-CoA reductase

✍ Scribed by H. Ferres; I.K. Hatton; L.J.A. Jennings; A.W.R. Tyrrell; D.J. Williams

Publisher: Elsevier Science
Year: 1983
Tongue: French
Weight: 258 KB
Volume: 24
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)94530-1

No coin nor oath required. For personal study only.

✦ Synopsis

A diastereoselective synthesis of 4(RS), 6(SR) -mercaptomethylmevalonolactone (1) is described in the course of the preparation of disulphides designed as inhibitors of HMGCoA reductase. Certain disulphides, e.g. glutathione-and coenzyme A-disulphides,are known to undergo C,3H1603S2 requires: C 54.90;

📜 SIMILAR VOLUMES

A New Synthesis of Key Intermediates for

A New Synthesis of Key Intermediates for the Preparation of 5,6-DiHETE and Lipoxin A4

✍ Agnès Gigou; Dr. Jean-Paul Lellouche; Dr. Jean-Pierre Beaucourt; Loïc Toupet; Dr 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 366 KB 👁 2 views

Methyl 3-0-benzyl-2,4,6-trideoxy-6-iodo-

Methyl 3-0-benzyl-2,4,6-trideoxy-6-iodo-α-d-erythro-hexopyranoside, a chiral synthon for the synthesis of inhibitors of HMG-CoA reductase

✍ John D. Prugh; Albert A. Deana 📂 Article 📅 1982 🏛 Elsevier Science 🌐 French ⚖ 240 KB

These compounds have a 4a-methyl group Jn the lactone rJng. For R3, R4 and R5 substltuents, Jn compounds & and i, see references 3 and 4.

Utilization of the chiral synthon, methy

Utilization of the chiral synthon, methyl 3-O-benzyl-2,4,6-trideoxy-6-iodo-α-D-erythro-hexopyranoside in the synthesis of a potent HMG-CoA reductase inhibitor

✍ John D. Prugh; C.Stanley Rooney; Albert A. Deana; Harri G. Ramjit 📂 Article 📅 1985 🏛 Elsevier Science 🌐 French ⚖ 246 KB

An efficient asymmetric catalytic hydrog

An efficient asymmetric catalytic hydrogenation of 4-aryl coumarins, preparation of a key intermediate in the synthesis of a class of endothelin receptor antagonists

✍ Michael A. McGuire; Susan C. Shilcrat; Edmund Sorenson 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 249 KB

The 4-aryl-3,4-dihydrocoumarin 1 is a critical intermediate in the synthesis of two endothelin receptor antagonists. Asymmetry is introduced by the chiral catalytic hydrogenation of 2. Reduction occurs only if the lactone is open (3). A number of chiral ruthenium and rhodium organometallic species a

ChemInform Abstract: Synthesis of 1,2,5,

ChemInform Abstract: Synthesis of 1,2,5,6-Tetrahydro-3-pyridinylalanine: A Key Intermediate in the Preparation of Thrombin Inhibitor UK-239,326.

✍ Paul V. Fish; Alan D. Brown; John C. Danilewicz; David Ellis; J. David Hardstone 📂 Article 📅 2009 🏛 John Wiley and Sons ⚖ 38 KB

A new class of condensing reagents for r

A new class of condensing reagents for rapid internucleotide bond formation in the phosphotriester approach and preparation of n3-benzoylthymidine as a key intermediate in oligodeoxyribonucleotide synthesis

✍ Jun-ichi Matsuzaki; Hitoshi Hotoda; Mitsuo Sekine; Tujiaki Hata 📂 Article 📅 1984 🏛 Elsevier Science 🌐 French ⚖ 265 KB