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A diastereoselective radical cyclisation approach to pyroglutamates

โœ Scribed by Karen Goodall; Andrew F. Parsons

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
252 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The 5-endo radical cyclisation of pyruvic acid derived dehydroalanines which contain chiral ester auxiliaries is reported. Cyclisation of the menthol ester derivative using Bu3SnH at 80ยฐC proceeded with low diastereoselectivity (1.

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An important reference has been unfortunately omitted : G. Stork & R. Mook Jr. (Tetrahedron Lett., 27, 4529 (1986)), recently reported such tin radical-mediated ethynyl cyclisations.