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A developmental study of the mutation “phocomelia” in the mouse

✍ Scribed by Sisken, Betty F. ;Gluecksohn-Waelsch, Salome

Publisher
John Wiley and Sons
Year
1959
Tongue
English
Weight
957 KB
Volume
142
Category
Article
ISSN
0022-104X

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✦ Synopsis

TWENTY FIGURES Some time ago we described the hereditary transmission as well as the morphological effects of a recessis-e mutation phocomelia in the mouse '56). Newborn mice hornozygous for this mutation show severe malformations of the head skeleton as well as of the limbs; the presence of a cleft palate is responsible for their inability to feed and for their subsequent death. Details of head abnormalities have been studied by Fitch ('57). Limb and head malformations are inherited as a gcnctic unit and are always found associated with each other. It appeared to be of great interest to undertake a developmental study of this mutation and to search for the possible mechanisms of the multiple effects of this particular genetic factor, phoeomelia. The results of studies of the limb abnormalities arc reported in this paper.

Methods

Embryos used in this investigation s17er.e derived from matings of +/pc females x +/pe males. The approximate time

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