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A degradation product of halobetasol propionate—Characterization and structure

✍ Scribed by Giancarlo Cravotto; Giovanni B. Giovenzana; Norberto Masciocchi; Giovanni Palmisano; Paolo Volante


Book ID
116892071
Publisher
Elsevier Science
Year
2007
Tongue
English
Weight
383 KB
Volume
72
Category
Article
ISSN
0039-128X

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📜 SIMILAR VOLUMES


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Actinobolin, an antibiotic obtained from a Streptomyces culture (2), has been shown to possess broad-spectrum antibacterial activity (3) as well as some antitumor (4, 5) and antileukemic (6) activity. Haskell and Bar&(z) reported an empirical formula of C,Haa\_,,N,O, for actinobolin free base.

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We report the identification and characterization of a novel degradation product associated with PEGylation of a recombinant protein. After several months of storage at 2 • C-8 • C, an unexpected increase was observed in the proportion of an impurity that eluted with the native unPEGylated protein b