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A cytoplasmic factor involved in the expression of resistance to C8-ATC in Saccharomyces cerevisiae

โœ Scribed by M. H. Misiewicz; Dr. Z. Kotylak

Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
430 KB
Volume
30
Category
Article
ISSN
0233-111X

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โœฆ Synopsis

A dozen mutants of Succhnroniyces cerevisiue, resistant to C8-ATC have been characterized. CR-ATC was previously established as a biologically toxic compound. Frequency of mutants (lo-') was typical for spontaneou? mutations. One very stable mutant was characterized extensively. The genetical analysis revealed that resistance in this mutant was determined by single-gene mutation. The rho" cclls. obtained by ethidiuni bromide (ER) mutagenesis of the resistant strain. werc completely devoid of resistance. A large percentage of rho cells, obtained by a moderate BB treatment of resistant cells werc still able to express resistance to ('8-ATC. Therefore wc hypothesized that. in our particular strain, a cytoplasmic factor is involved in nuclear determination of resistance.

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