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A Cyclosporin Derivative Discriminates between Extracellular and Intracellular Cyclophilins

✍ Scribed by Miroslav Malešević; Jan Kühling; Frank Erdmann; Molly A. Balsley; Michael I. Bukrinsky; Stephanie L. Constant; Gunter Fischer


Book ID
101569710
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
421 KB
Volume
49
Category
Article
ISSN
0044-8249

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The interaction of cyclosporin \(A\) and cyclosporin derivatives with cyclophilins \(A, B\), and \(C\) has been investigated by means of fluorescence measurement techniques. Since Trp-121 of cyclophilin \(A\) is in close contact with bound cyclosporins and changes its fluorescence emission upon bind