✍ Scribed by Gracián Triviño; María Concepción Serrano; Raffaella Pagani; María Teresa Portolés
No coin nor oath required. For personal study only.
Summary: A customized instrument has been developed as part of multidisciplinary research work relating to the development of a biodegradable vascular scaffold. This instrument aims to measure the mechanical properties of elastic and viscoelastic thin membranes with tissue engineering applications. Uniform and omni‐directional pressure is applied on the whole membrane which is uniformly clamped and submerged into a liquid medium. The mechanical testing described in this study is focused on the stress‐strain curves of polycaprolactone (PCL) films after different treatments. The influence of Dulbecco's modified Eagle's culture medium, L929 fibroblast culture, NaOH treatment and film thickness on the mechanical properties of PCL films was evaluated after different times. These studies show that the PCL degradation process is influenced by immersion in the culture medium, inducing an increment in the slope of the pressure‐dilation curve which is indicative of an increase in the polymer stiffness. On the other hand, long NaOH treatments make PCL films have more flexible behavior.
A computerized version of the instrument: (1) Electrical compressor; (2) Filter; (3) Voltage‐pressure converter; (5) Pressure sensor; (6) Differential pressure sensor; (7–8) Main and auxiliary pipettes; (9) Printed circuit board; (10) Personal computer.
magnified imageA computerized version of the instrument: (1) Electrical compressor; (2) Filter; (3) Voltage‐pressure converter; (5) Pressure sensor; (6) Differential pressure sensor; (7–8) Main and auxiliary pipettes; (9) Printed circuit board; (10) Personal computer.
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