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A Cryptic Proofreading 3′→ 5′Exonuclease Associated with the Polymerase Subunit of the DNA Polymerase-Primase from Drosophila melanogaster

✍ Scribed by Susan M. Cotterill, Mary E. Reyland, Lawrence A. Loeb and I. R. Lehman


Book ID
123634573
Publisher
National Academy of Sciences
Year
1987
Tongue
English
Weight
955 KB
Volume
84
Category
Article
ISSN
0027-8424

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✍ Odilia Popanda; Claudia Flohr; Jia-Chun Dai; Andreas Hunzicker; Heinz Walter Thi 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 227 KB

Mutated constituents of the DNA replication complex might contribute to the mutational load of the genome during tumor development by impairing DNA synthesis as well as cell cycle-related control of DNA replication. To prove or disprove this hypothesis, we looked for mutations in the cDNA sequences