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A Coupled HPLC/Radioimmunoassay for Analysis of Zidovudine Metabolites in Mononuclear Cells

✍ Scribed by Stretcher, B. N.; Pesce, A. J.; Geisler, B. A.; Vine, W. H.

Book ID
118048991
Publisher
Informa UK (Taylor & Francis)
Year
1991
Tongue
English
Weight
469 KB
Volume
14
Category
Article
ISSN
0148-3919

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Zidovudine (ZDV, AZT) is the first clinically effective drug licensed for use in the treatment of human immunodeficiency virus (HIV) infection. Activation of ZDV requires phosphorylation to ZDV triphosphate by cellular kinases. It is important, therefore, to determine the intracellular levels of the