A Copper-Catalyzed Method for the Facially Selective Addition of Grignard Reagents to Cyclopropenes
β Scribed by Liao, Lian-an; Fox, Joseph M.
- Book ID
- 127387721
- Publisher
- American Chemical Society
- Year
- 2002
- Tongue
- English
- Weight
- 72 KB
- Volume
- 124
- Category
- Article
- ISSN
- 0002-7863
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π SIMILAR VOLUMES
Methods for the annulation of five-membered rings onto pre-existing carbon skeletons are valuable in the synthesis of several classes of natural products.1,2 In this communication we wish to report a method based upon the general concept illustrated in equation 1. This approach is based upon the con
The copper-catalyzed conjugate addition of Grignard reagents to enones in the presence of chiral diselenide oxazoline ligands has been studied and found to provide good yields and useful levels of asymmetric induction.
The copper catalyzed conjugate addition of n-butyl Grignard to enones in the presence of chiral ferrocenyl phosphine oxazoline ligands has been studied and found to provide useful levels of asymmetric induction. A comparison of the ferrocene derived ligands 3 and 6 with the corresponding phenyl deri
## Abstract For Abstract see ChemInform Abstract in Full Text.