A synthesis of the spiroketal subunit of
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Barry M. Trost; John A. Flygare
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Article
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1994
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Elsevier Science
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French
⚖ 302 KB
Using a Ru catalyzed cyclixation-addition, a short synthesis of the spiroketal core corresponding to the natural enantiomer of (-)-calyculin A from R-pantolactone emerges. Calyculin A (1). isolated from the marine sponge Discodennia calyx, is a nanomolar inhibitor of two of the