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A convergent carbohydrate approach to the synthesis of taxol. Part 2. Ring C subunit

โœ Scribed by Mikhail S. Ermolenko; Gabor Lukacs; Pierre Potier


Publisher
Elsevier Science
Year
1995
Tongue
French
Weight
210 KB
Volume
36
Category
Article
ISSN
0040-4039

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The synthesis of methyl (4R, 8RJ-lO-bromo-8-methyl-4-( 1,3,6-trioxaheptane)-2-deceneoate (3, a synthon for the construction of the macrocyclic moieties of the cytochalasins A (l), B (2), F (3) and desoxaphomin (4) is described. (S)-Glutamic acid (6) was transformed to the C,-epoxide 10 and 3-methylg