A convenient tool for studying the stability of proteins and nucleic acids
✍ Scribed by Concetta Giancola
- Publisher
- Springer Netherlands
- Year
- 2007
- Tongue
- English
- Weight
- 145 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0022-5215
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## Abstract __Intercalating nucleic acids (INA®s) with insertions of (__R__)‐1‐__O__‐(1‐pyrenylmethyl)glycerol were hybridized with locked nucleic acids (LNAs). INA/LNA duplexes were found to be less stable than the corresponding DNA/LNA duplexes when the INA monomer was inserted as a bulge close t
## Abstract | I. | Introduction | 306 | | II. | Supramolecular Structure Characterization | 308 | | | A. A Protein Is Used as a “Hook” | 309 | | | 1. Immuno‐Precipitation | 309 | | | 2. Tagging with a Poly‐Histidine Sequence | 310 | | | 3. Direct Analysis of Large Protein Complexes | 3