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A convenient method for the preparation of terminal methyl phosphates of nucleic acids

✍ Scribed by C. T. J. Wreesmann; Y. Th. van den Hoogen; A. H. Ledeboer; G. A. van der Marel; J. H. van Boom

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
871 KB
Volume
104
Category
Article
ISSN
0165-0513

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A one-step conversion of carboxylic acid to hydroxamic acid, under neutral pH conditions is described. This simple, selective and ecient method was applied to a wide range of aliphatic/aromatic carboxylic acid derivatives that contain hydroxyl, halo, ester and other base sensitive groups as substitu