A convenient method for the preparation of hydroxamic acids

✍ Scribed by A.Sekar Reddy; M.Suresh Kumar; G.Ravindra Reddy

• Publisher: Elsevier Science
• Year: 2000
• Tongue: French
• Weight: 130 KB
• Volume: 41
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(00)01058-3

✦ Synopsis

A one-step conversion of carboxylic acid to hydroxamic acid, under neutral pH conditions is described. This simple, selective and ecient method was applied to a wide range of aliphatic/aromatic carboxylic acid derivatives that contain hydroxyl, halo, ester and other base sensitive groups as substituents. The method utilizes cheaply available reagents and hence it is a practical and cost eective strategy, compared to the other methods available in the literature.