A convenient synthesis of vitamin D3-9, 19-3H and the mechanism of the previtamin D3 Vitamin D3 reaction
โ Scribed by M. Akhtar; C.J. Gibbons
- Publisher
- Elsevier Science
- Year
- 1965
- Tongue
- French
- Weight
- 133 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0040-4039
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A synthesis of 25hydroxy [23,24JH]vitamin D3 leading to a radiochemically pure product with a specific activity of 78 Wmmol is described. The structure of the product was confirmed by comparison with unlabeled material and its biological activity was established by in vitro conversion to la,25dihydr
T'he efficient degradation of 1 to the a-methylene ketone 4 is described. Compomd 4 ljas then COitlveAed to the al,ly2'ic a',cohol
In existing total syntheses 192 of vitamin D 3 the conjugated triene system is not constructed directly; instead, an isomeric triene, either 5-trans-vitamin D31b or precalcifero13,2 is first elaborated, and is then transformed into the vitamin itself by photochemical or thermal isomerisation. Vitam