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A convenient synthesis of trisubstituted pyrido[2,3-d]pyrimidin-7-ones

✍ Scribed by Jiri Kasparec; Jerry L. Adams; Joseph Sisko; Domingos J. Silva

Book ID: 104253689
Publisher: Elsevier Science
Year: 2003
Tongue: French
Weight: 99 KB
Volume: 44
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(03)00974-2

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✦ Synopsis

A novel, highly efficient and scalable route for the synthesis of trisubstituted pyrido[2,3-d]pyrimidin-7-ones was developed. The target compounds were synthesized in five steps from readily available reagents in about 40% overall yield.

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