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A convenient synthesis of substituted piperazines via aminomercuration-demercuration of diallylamines

✍ Scribed by J. Barluenga; C. Nájera; M. Yus

Book ID
112126074
Publisher
Journal of Heterocyclic Chemistry
Year
1980
Tongue
English
Weight
329 KB
Volume
17
Category
Article
ISSN
0022-152X

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A stereospecific synthesis of tetra-subs
A stereospecific synthesis of tetra-substituted chiral piperazines
✍ Raid J. Abdel-Jalil; Raed A. Al-Qawasmeh; Yousef Al-Abed; Wolfgang Voelter 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 123 KB

A one pot reaction of the epoxy triflates 1 or 2 with a variety of N,N'-disubstituted ethylenediamines yields the corresponding chiral piperazine derivatives 3a-e and 4a-e of potential pharmacological interest in high yields.