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A Convenient Synthesis of Protoanemonin

โœ Scribed by Crey, Caroline; Dumy, Pascal; Lhomme, Jean; Kotera, Mitsuharu


Book ID
120836936
Publisher
Taylor and Francis Group
Year
2003
Tongue
English
Weight
162 KB
Volume
33
Category
Article
ISSN
0039-7911

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Acylation of 3-methyl-2,3-bis(trimethylsiloxy)-1-butene (PhLi) with (E)-2-methyl-2-butenoyl chloride gives the corresponding 3(2H)-furanone derivative, which can be readily converted to the naturally occurring antitumor agent Geiparvarin by two steps. Recently, considerable attention has been attrac