A convenient synthesis of phosphoenolpyruvate via silyl-ester intermediate

✍ Scribed by Mitsuo Sekine; Tetsuaki Futatsugi; Kohji Yamada; Tsujiaki Hata

• Book ID: 104237207
• Publisher: Elsevier Science
• Year: 1980
• Tongue: French
• Weight: 156 KB
• Volume: 21
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)85476-9

✦ Synopsis

Phosphoenolpyruvate was synthesized in high yield by a simple procedure starting from pyruvic acid and dimethyl trimethylsilyl phosphite through trimethylsilylation, bromination, and the Perkow reaction. The concept of "high energy phosphate bond" was originally proposed by Lipman in 1941. 2) Several types of high energy phosphates such as phosphoenolpyruvate (PEP), phosphocreatine, and acetyl phosphate were listed. They make a role of phosphate-transfer reaction involving ATP synthesis in biological systems Cramer3) has studied 'Zur Chemie der energiereichen Phosphate' and proposed