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A convenient synthesis of macrocyclic lactams

✍ Scribed by Qian Ligang; Sun Zhong; Deffo Tamboue; Kristin Bowman Mertes

Publisher
Elsevier Science
Year
1990
Tongue
French
Weight
266 KB
Volume
31
Category
Article
ISSN
0040-4039

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✦ Synopsis

SuMMAfM

A facile method is described for the synthesis of macrocyclk lactams using dkarboxytk adds and dtamines dtrectty in the presence of diphenyfphosphoryt a&b.

Macrocyclk polyamines have been shown to complex a variety of inorganic and organic ions.1 Recent devebpments in ankn comptexatbn try synthetic polyammonium molecdes have created a new field for the design of molecular receptors capable of selecttvety and strongly htndfng anionic substrates, thus extending supramofecufar chemistry to anions as well as cations. Advances in the application of these macrccycles in order to study the ccmplexatkn of cations and anions, however, rely critkalty on versatile methods of synthesis. Of contemporary interest is the assembly of sophistkated ring systems, such as spherical and cylindrical macrocycles,2-4 and those with various functional side chains.sns Macrocyclk lactams are

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