A convenient synthesis of enaminones using tandem acetonitrile condensation, Grignard addition

✍ Scribed by Anthony R. Haight; Timothy L. Stuk; Jerome A. Menzia; Timothy A. Robbins

• Book ID: 104257226
• Publisher: Elsevier Science
• Year: 1997
• Tongue: French
• Weight: 170 KB
• Volume: 38
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(97)00866-6

✦ Synopsis

Ritonavir (Norvir®), 1, is an H1V-I protease inhibitor that recently received FDA regulatory approval for the treatment of HIV infection. I Retrosynthetically, Ritonavir requires the pseudosymmetric diaminoalcohol core unit 2. 2

We recently reported an efficient route for the large scale synthesis of 2. 3 This approach involves the synthesis of