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A convenient synthesis of a lipopeptide containing a diacylglycerol moiety: Preparation of a potential inhibitor of protein kinase C

✍ Scribed by H. B. A. de Bont; J. H. van Boom; R. M. J. Liskamp

Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
506 KB
Volume
111
Category
Article
ISSN
0165-0513

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✦ Synopsis

Abstract

The synthesis of a dimyristoylglycerol peptide is reported. Starting from 1,2‐diisopropylidene‐sn‐glycerol, a 1,2‐dimyristoyl‐sn‐glycerol derivative has been synthesized which has been coupled to an immobilized peptide. After deprotection and cleavage from the resin, a diacylglycerol‐moiety‐containing lipopeptide was obtained which can be considered as a potential inhibitor of protein kinase C.

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