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A convenient synthesis of [3-3H]squalene and [3-3H]-2,3-oxidosqualene

✍ Scribed by Maurizio Ceruti; Giorgio Grosa; Flavio Rocco; Franco Dosio; Luigi Cattel

Publisher
John Wiley and Sons
Year
1994
Tongue
French
Weight
421 KB
Volume
34
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

[3‐^3^H]Squalene and [3‐^3^H]‐2,3‐oxidosqualene, key compounds for studying the biosynthesis of sterols, were synthesized. The main step was a modified Wittig reaction of [1‐^3^H]trisnorsqualene aldehyde with a phosphorus ylide to give [3‐^3^H]squalene or with a sulfur ylide to give [3‐^3^H]‐2,3‐oxidosqualene. These compounds were obtained in high radiochemical yield and high purity under simple conditions.

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