A Convenient Synthesis of 2-Arylnaphtho[1,2-d]oxazole Derivatives Promoted by Triethylamine
✍ Scribed by Hong LI; Kun WEI; Yang-Jie WU
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 94 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0256-7660
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✦ Synopsis
Abstract
A variety of 2‐arylnaphtho[1,2‐d]oxazole derivatives were efficiently synthesized in moderate to high yields by the reaction of aromatic aldehydes with 1‐amino‐2‐naphthol derivatives in the presence of triethylamine in refluxing ethanol in air. Seven new 2‐arylnaphtho[1,2‐d]oxazole derivatives were obtained and characterized by the spectral data and elemental analysis. In addition, the X‐ray crystal structures of 2‐[4‐(N,N‐dimethylamino)phenyl]naphtho[1,2‐d] oxzole (3d) and 1,1′‐bis(naphtho[1,2‐d]oxazol‐2‐yl)ferrocene (3n) have been determined.
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## Abstract magnified image A novel method for the synthesis of 1,2‐dihydro‐5‐arylnaphtho[2,1‐__c__][2,7]naphthyridine derivatives via a three‐component reaction of aromatic aldehyde, naphthalen‐2‐amine, and __N__‐substituted piperidin‐4‐one derivatives is described using 5 mol % iodine as catalyst