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A convenient synthesis of 1H-2,3-benzoxazines by an acid-catalyzed intramolecular Mitsunobu reaction

✍ Scribed by Hiroyuki Kai; Toru Nakai

Publisher: Elsevier Science
Year: 2001
Tongue: French
Weight: 61 KB
Volume: 42
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(01)01406-x

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✦ Synopsis

A convenient, efficient method for the preparation of benzoxazines is described. 2-(Hydroxyiminomethyl)benzyl alcohols were cyclodehydrated to construct 1H-2,3-benzoxazines by acid-catalyzed intramolecular Mitsunobu reaction. This reaction depended on the geometry of the hydroxyimino moiety in the reaction precursor.

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