## carbonyl compounds with sofr rlectrophiles restdted in intramolectdar aYsplacement of the stt@nyl group by the wrbonyl to give ~butyrolactones. This novel cyclisation wrks best for bznzylic svlfaridcs and provides a concise route to ttans-#J~ttbstitttted lactones with high stereoselectivity. Co
A convenient stereoselective route to novel tetrahydroxyindolizidines
✍ Scribed by Ana T. Carmona; José Fuentes; Inmaculada Robina
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- French
- Weight
- 186 KB
- Volume
- 43
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
The stereoselective synthesis of cis\_ chrysanthemic acid has been achievedfrom 2,2-dimethyl dimedone by a short sequence of eficient reactions.
In the preceding communication, we described an efficient coupling reaction of a,a'-dibromo ketones and furan. We demonstrate here that the adducts can readily be converted to troponoid compounds.
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A strategy using a highly stereoselective Claisen-Ireland rearrangement followed by a Grubbs metathesis afforded in a good overall yield after further functionalisation a potentially synthetic precursor of fumagillin and ovalicin.