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A Convenient Procedure for Carboxylation—Robinson Annulations of Ketones Using Triethylamine Base in the Presence of Magnesium Chloride

✍ Scribed by Olsen, Richard S.; Fataftah, Zakaria A.; Rathke, Michael W.


Book ID
111674266
Publisher
Taylor and Francis Group
Year
1986
Tongue
English
Weight
179 KB
Volume
16
Category
Article
ISSN
0039-7911

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The title process has been accomplished by a three-step sequence involving protection of aldeh;de as the imine, in situ reduction of ketone with lithium tri-tert-butoxyaluminohydride, and regeneration of aldehyde on hydrolytic work-up. The preferential in situ ketalization or hydration of aldehydes