𝔖 Bobbio Scriptorium
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A convenient one-pot procedure for the selective reduction of ketones in the presence of aldehydes

✍ Scribed by Mario Paglialunga Paradisi; Giampiero Pagani Zecchini; Giorgio Ortar

Publisher
Elsevier Science
Year
1980
Tongue
French
Weight
212 KB
Volume
21
Category
Article
ISSN
0040-4039

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✦ Synopsis

The title process has been accomplished by a three-step sequence involving protection of aldeh;de as the imine, in situ reduction of ketone with lithium tri-tert-butoxyaluminohydride, and regeneration of aldehyde on hydrolytic work-up.

The preferential in situ ketalization or hydration of aldehydes relative to ketones using a lanthanoid ion as the catalyst have been recently exploited in the first two one-pot methods for the selective reduction of a keto group in the presence of an aldehyde.

' Isomeric purity. The original geranial WEW 97% pure; thus, only a negligible isomerization to neral has taken place.

πŸ“œ SIMILAR VOLUMES

One-Pot Addition/Reduction Procedure for
One-Pot Addition/Reduction Procedure for the Synthesis of -Amino Alcohols from -Enamino Ketones
✍ Cristina Cimarelli; Sandra Giuli; Gianni Palmieri πŸ“‚ Article πŸ“… 2006 πŸ› John Wiley and Sons 🌐 English βš– 147 KB

## Abstract γ‐Amino alcohols **3** have been synthesized by the addition of organolithium reagents to β‐enamino ketones **1** followed by one‐pot reduction with sodium triacetoxyborohydride. The method allows the stereoselective synthesis of γ‐amino alcohols in which the hydroxy group is bonded to