A Convenient Preparation of Trifluoroacetonitrile: Application to the Synthesis of a Novel Pyrimidinone Building Block
β Scribed by Parker, Marshall H.
- Book ID
- 120247441
- Publisher
- Taylor and Francis Group
- Year
- 2004
- Tongue
- English
- Weight
- 120 KB
- Volume
- 34
- Category
- Article
- ISSN
- 0039-7911
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
a-Fluorophenylacetonitriles (31 are readily prepared by the treatment of the corresponding benzaldehyde cyanohydrin trimethylsilylethers (2) with diethylaminosulfur trifluoride (DASTI. This method for the introduction of fluorine alpha to a cyano group iS also applicable to the cyanohydrin trimethyl
Readily available 6-isobutyrylaminopurine can replace either a primary or secondary OH group under Mitsunobu conditions and provide an effkient synthesis of carbocyclic analogs of adenosine. X-my data indicates that only tbe desired @-substituted derivatives of adenine are formed.