A convenient preparation of protected 3′-deoxyguanosine from guanosine
✍ Scribed by Gong-Xin He; Norbert Bischofberger
- Book ID
- 103406352
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- French
- Weight
- 192 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
Highly efficient synthesis of protected 3%-deoxyadenosine and 3%-deoxyguanosine from adenosine and guanosine were described. The 2%,3%-diol of protected adenosine and guanosine were reacted with a-acetoxyisobutyryl bromide to yield 9-(2%-Oacetyl-3%-bromo-5%-O-tert-butyldiphenylsilyl-3%-deoxy-b-D-xyl
## Abstract 3′‐Amino‐3′‐deoxyguanosine was synthesized from guanosine in eight steps and 58% overall yield. The 2′,3′‐diol of 5′‐__O__‐[(__tert__‐butyl)diphenylsilyl]‐2‐__N__‐[(dimethylamino)methylidene]guanosine was reacted with __α__‐acetoxyisobutyryl bromide and treated with 0.5n NH~3~ in MeOH t