A convenient preparation of high specific activity tritiated estrogens
β Scribed by M.M. Coombs; H.R. Roderick
- Book ID
- 119480998
- Publisher
- Elsevier Science
- Year
- 1968
- Tongue
- English
- Weight
- 399 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0039-128X
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Due to the desire for biological assay techniques of greater sensitivity and specificity than presently exist for the antihypertensive drug guanethidine, tritium labeled guanethidine of high specific activity was prepared for use in radioimmunoassay procedures. This drug has been labeled in other po
## Abstract The synthesis of the trichloromethyl analogue of benzyloxycarbonylβthreonine is described. This precursor was reduced by tritium gas to give [methylβ^3^H~3~]βthreonine and its allo isomer. They were separated by HPLC using a chiral stationnary phase. They have a molar specific activity